What is a common cause of nonpitting periorbital edema and thinned hair in a patient?

Severe hypothyroidism is commonly associated with nonpitting periorbital edema and thinned hair due to its impact on metabolism and fluid retention. In hypothyroidism, the thyroid hormone levels are low, which leads to a decreased metabolic rate and can result in various signs and symptoms.

The nonpitting periorbital edema occurs because of the accumulation of glycosaminoglycans in the interstitial tissues, leading to a swelling effect around the eyes. This specific type of edema does not retain an indentation when pressure is applied, distinguishing it from pitting edema.

Additionally, thinned hair is a consequence of the hormonal imbalance in severe hypothyroidism. The lack of thyroid hormones affects the hair growth cycle, leading to hair loss and changes in hair texture.

These clinical manifestations are directly linked to the body's slowed metabolism and altered fluid dynamics due to inadequate thyroid hormone production, making severe hypothyroidism a well-recognized cause of these symptoms.