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To differentiate anxiety from hyperthyroidism in a male patient, which test should be performed?

  1. Free cortisol

  2. Electrocardiogram

  3. PHQ-9 screening

  4. TSH and free T4

The correct answer is: TSH and free T4

To differentiate anxiety from hyperthyroidism in a male patient, measuring thyroid-stimulating hormone (TSH) and free thyroxine (T4) levels is essential. Hyperthyroidism can present with symptoms that overlap with anxiety, such as increased heart rate, nervousness, and irritability. TSH is produced by the pituitary gland and regulates thyroid hormone production. Elevated levels of free T4, a crucial thyroid hormone, indicate hyperthyroidism, which occurs when the thyroid gland is overactive. By conducting the TSH and free T4 test, healthcare professionals can assess the thyroid function accurately. If the results show low TSH levels and elevated free T4, it confirms hyperthyroidism as the underlying cause of the symptoms. In contrast, normal thyroid levels would suggest that the symptoms are likely stemming from anxiety or other non-thyroid-related issues. Other tests like free cortisol might evaluate adrenal function, but they do not specifically distinguish between anxiety and hyperthyroidism. An electrocardiogram can aid in assessing cardiac function related to hyperthyroidism but will not provide information on thyroid levels. Lastly, the PHQ-9 screening tool focuses on depressive symptoms rather than specifically addressing anxiety or thyroid-related concerns, making it less relevant for