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Which symptom associated with acanthosis nigricans would be concerning in a patient suspecting insulin resistance?

  1. Skin tags.

  2. Hyperglycemia.

  3. Obesity.

  4. Fatigue.

The correct answer is: Skin tags.

Acanthosis nigricans is a skin condition characterized by dark, velvety patches in body folds and creases, often seen in individuals with insulin resistance. In the context of insulin resistance, the presence of skin tags can indeed be concerning. Skin tags, or acrochordons, are small, benign tumors that can appear on the skin, particularly in areas subjected to friction. Their presence can suggest a higher likelihood of metabolic syndrome, a cluster of conditions that include insulin resistance. Skin tags often develop in individuals who are overweight or have other indicators of insulin resistance, such as acanthosis nigricans itself. This association can imply that the body is struggling with insulin regulation, increasing the risk of developing more serious complications, including type 2 diabetes. Other symptoms mentioned, such as hyperglycemia, obesity, and fatigue, can also be associated with insulin resistance, but they are more general indicators of metabolic issues rather than specific symptoms linked directly to the skin condition of acanthosis nigricans. Hyperglycemia can occur in various contexts, not solely related to acanthosis nigricans. Obesity is a risk factor rather than a direct symptom of insulin resistance, and fatigue is often a nonspecific symptom related to various