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What class of medications is considered first-line management for both PTSD and major depressive disorder?

  1. Selective serotonin reuptake inhibitors

  2. Non-selective dopamine reuptake inhibitors

  3. Mood stabilizers

  4. Monoamine oxidase inhibitors

The correct answer is: Selective serotonin reuptake inhibitors

Selective serotonin reuptake inhibitors (SSRIs) are recognized as the first-line treatment for both post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). SSRIs work by increasing serotonin levels in the brain, which can help regulate mood and anxiety. This mechanism is particularly beneficial for individuals experiencing the anxiety and depressive symptoms commonly associated with PTSD and MDD. Research and clinical guidelines support the use of SSRIs in these conditions due to their efficacy, safety profile, and tolerability compared to other classes of medications. They help alleviate symptoms such as sadness, intrusive thoughts, and hyperarousal in PTSD, as well as the pervasive low mood characteristic of MDD. As first-line treatments, SSRIs are often preferred by healthcare providers due to their widespread acceptance in clinical practice and the robust evidence supporting their use across various populations.