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In a patient with acanthosis nigricans, which physical finding is commonly associated?

  1. Central obesity.

  2. Severe malnutrition.

  3. Scaphoidal abdomen.

  4. Body mass index (BMI) of 22.

The correct answer is: Central obesity.

Acanthosis nigricans is characterized by the dark, velvety thickening of the skin, typically found in body folds and creases, and is often associated with conditions such as insulin resistance and obesity. The condition reflects underlying metabolic issues, frequently linked with obesity, particularly central obesity, which is the accumulation of fat in the abdominal area. Central obesity is a common physical finding associated with acanthosis nigricans due to the correlation between excess insulin levels and the body's response to it, leading to skin changes. This connection highlights how obesity can impact cellular processes, contributing to the development of the skin condition. The presence of central obesity not only provides a visual cue but also indicates potential risks for related conditions, such as type 2 diabetes and cardiovascular diseases. In contrast, severe malnutrition, a scaphoidal abdomen, and a body mass index of 22 do not typically correlate with acanthosis nigricans. Severe malnutrition often leads to weight loss and a frail appearance, which would not support the development of acanthosis nigricans. A scaphoidal abdomen suggests malnourishment or a lack of body fat rather than excess weight. A body mass index of 22 is generally considered normal, thus